I-Niclosamide Bolus 1250 mg
I-Niclosamide Bolus ivimbela i-phosphorylation ku-mitochondria ye-cestodes.Kokubili i-in vitro ne-vivo, i-scolex ne-proximal segment ibulawa lapho kuthintana nomuthi.I-scolex ekhululiwe ingase igaywe emathunjini;ngakho-ke, kungase kungenzeki ukuhlonza i-scolex endle.I-Niclosamide Bolus i-taenic acid esenzweni futhi ayigcini nje kuphela amasegimenti kodwa futhi i-scolex.
Umsebenzi we-Niclosamide Bolus ngokumelene nezikelemu ubonakala ubangelwa ukuvinjelwa kwe-mitochondrial oxidative phosphorylation;Ukukhiqizwa kwe-ATP ye-anaerobic nakho kuyathinteka.
Umsebenzi we-cestocidal we-Niclosamide Bolus ubangelwa ukuvinjwa kokumuncwa kwe-glucose yi-tapeworm kanye nokuqaqa inqubo ye-oxidative phosphorylation ku-mitochondria ye-cestodes.I-lactic acid eqoqiwe ebangelwa ukuvinjwa komjikelezo we-Krebs ibulala izikelemu.
Izinkomba
I-Niclosamide Bolus ikhonjiswe kuzo zombili izikelemu zetapeworm ezihlasela imfuyo, izinkukhu, izinja namakati kanye nakuma-immature paramphistomiasis (Amphistomiasis) yezinkomo, Izimvu nezimbuzi.
Izikelemu ze-tapeworm
Izinkomo, Izimbuzi Zezimvu kanye Nezinyamazane: I-Moniezia Species Thysanosoma (izikelemu ze-Fringed Tape)
Izinja: I-Dipylidium Caninum, i-Taenia Pisiformis T. hydatigena ne-T. taeniaeformis.
Amahhashi: Ukutheleleka kwe-Anoplocephalid
Izinkukhu: URaillietina noDavainea
I-Amphistomiasis: (I-Paramphistomes Engakabikho)
Ezinkomeni nasezimvini, i-Rumen flukes (izinhlobo ze-Paramphistomum) ivame kakhulu.Nakuba ama-flukes amadala axhunywe odongeni lwe-rumen angase abe nokubaluleka okuncane, lawo angavuthiwe adala umonakalo omkhulu nokufa ngenkathi efuduka odongeni lwe-duodenal.
Izilwane ezibonisa izimpawu ze-anorexia enzima, ukwanda kwamanzi, kanye nesifo sohudo esinamanzi kufanele kusolwelwe ukuthi sine-amphistomiasis futhi zelashwe ngokushesha nge-Niclosamide Bolus ukuvimbela ukufa nokulahlekelwa ukukhiqizwa njengoba i-Niclosamide Bolus ihlinzeka ngokusebenza ngempumelelo okuphezulu ngokungaguquguquki ezifweni ezingavuthiwe.
Ukwakheka
I-bolus ngayinye engagcotshiwe iqukethe:
I-Niclosamide IP 1.0 gm
Ukuphatha kanye nesilinganiso
I-Niclosamide Bolus ekuphakeleni noma kanjalo.
Ngokumelene nezikelemu zeTapeworms
Izinkomo, Izimvu Namahhashi: 1 gm bolus ngesisindo somzimba esingama-20 kg
Izinja namakati: 1 gm bolus ngesisindo somzimba esingu-10 kg
Izinkukhu: 1 gm bolus yezinyoni ezi-5 ezindala
(Cishe i-175 mg ngekhilogremu yesisindo somzimba)
Ngokumelene nama-Amphistomes
Izinkomo Nezimvu:Umthamo omkhulu ngesilinganiso se-1.0 gm bolus / 10 kg isisindo somzimba.
Ukuphepha:I-Niclosamide bolus inomkhawulo obanzi wokuphepha.Ukweqisa kwe-Niclosamide izikhathi ezingama-40 ezimvini nasezinkomeni kutholakale ukuthi akunabo ubuthi.Ezinjeni nasemakati, umthamo ophindwe kabili onconywayo awubangeli imiphumela emibi ngaphandle kokuthamba kwendle.I-Niclosamide bolus ingasetshenziswa ngokuphepha kuzo zonke izigaba zokukhulelwa nasezifundweni ezikhubazekile ngaphandle kwemiphumela emibi.
