I-Niclosamide Bolus 1250 mg
I-Niclosamide Bolus ivimbela i-phosphorylation kuma-mitochondria e-cestodes. Kokubili ku-vitro kanye naku-vivo, izingxenye ze-scolex kanye neziseceleni eziseduze ziyabulawa lapho zithintana nomuthi. I-scolex ekhululekile ingagaywa emathunjini; ngakho-ke, kungase kungenzeki ukuhlonza i-scolex endle. I-Niclosamide Bolus ibulala i-taenical futhi ayiqedi izingxenye kuphela kodwa futhi iqeda ne-scolex.
Umsebenzi we-Niclosamide Bolus ngokumelene nezibungu kubonakala sengathi ubangelwa ukuvinjelwa kwe-phosphorylation ye-mitochondrial oxidative; ukukhiqizwa kwe-ATP engashukumi nakho kuyathinteka.
Umsebenzi we-cestocidal we-Niclosamide Bolus ubangelwa ukuvinjelwa kokumuncwa kwe-glucose yi-tapeworm kanye nokuhlanganiswa kwenqubo ye-oxidative phosphorylation ku-mitochondria yama-cestodes. I-lactic acid eqongelelekile evela ekuvinjweni komjikelezo we-Krebs ibulala izibungu.
Izinkomba
I-Niclosamide Bolus iboniswa kokubili ekuhlaselweni yizibungu zezilwane, izinkukhu, izinja namakati kanye ne-paramphistomiasis engakavuthwa (i-Amphistomiasis) yezinkomo, izimvu nezimbuzi.
Izimpethu ze-tapeworm
Izinkomo, Izimvu Izimbuzi Nezinyamazane: Izinhlobo zeMoniezia I-Thysanosoma (Izibungu Ezinezintambo Ezigobile)
Izinja: I-Dipylidium Caninum, i-Taenia Pisiformis T. hydatigena ne-T. taeniaeformis.
Amahhashi: Ukutheleleka kwe-Anoplocephalid
Izinkukhu: Raillietina kanye neDavainea
I-Amphistomiasis: (Ama-paramphistomes angavuthiwe)
Ezinkomeni naseMvuni, ama-Rumen fluke (uhlobo lwe-Paramphistomum) avame kakhulu. Nakuba ama-Rumen fluke amadala anamathele odongeni lwe-rumen angaba angabalulekile kangako, lawo angakavuthwa abangela izifo ezinkulu kanye nokufa ngenkathi ethuthela odongeni lwe-duodenal.
Izilwane ezibonisa izimpawu ze-anorexia enzima, ukuphuza amanzi amaningi, kanye nesifo sohudo esinukayo kufanele kusolwe ukuthi sine-amphistomiasis futhi zelashwe ngokushesha nge-Niclosamide Bolus ukuvimbela ukufa nokulahlekelwa umkhiqizo ngoba i-Niclosamide Bolus inikeza ukusebenza okuphezulu kakhulu ngokumelene nezimpukane ezingakavuthwa.
Ukwakheka
I-bolus ngayinye engagqokwanga iqukethe:
I-Niclosamide IP 1.0 gm
Ukuphathwa kanye nomthamo
I-Niclosamide Bolus ekudleni noma kanjalo.
Ngokumelene nezikelemu
Izinkomo, Izimvu Namahhashi: 1 gm bolus yesisindo somzimba esingu-20 kg
Izinja namakati: 1 gm bolus yesisindo somzimba esingu-10 kg
Izinkukhu: 1 gm bolus yezinyoni ezi-5 ezindala
(Cishe 175 mg ngekhilogremu yesisindo somzimba)
Ngokumelene nama-Amphistomes
Izinkomo Nezimvu:Isilinganiso esiphezulu ngesilinganiso se-1.0 gm bolus / isisindo somzimba esingu-10 kg.
Ukuphepha:I-Niclosamide bolus inomkhawulo omkhulu wokuphepha. Ukweqisa i-Niclosamide izikhathi ezifika kwezingama-40 ezimvwini nasezinkomeni kutholakale ukuthi akunabo ubuthi. Ezinjeni nasemakatini, isilinganiso esiphindwe kabili esinconywayo asibangeli imiphumela emibi ngaphandle kokuthamba kwendle. I-Niclosamide bolus ingasetshenziswa ngokuphephile kuzo zonke izigaba zokukhulelwa kanye nakubantu ababuthakathaka ngaphandle kwemiphumela emibi.
