Imikhiqizo yethu
UNiclosamide Bolus 1250 mg
UNiclosamide Bolus uvimbela i-phosphorylation ku-mitochondria yama-cestode. Kokubili i-in vitro naku-vivo, izingxenye ze-scolex kanye ne-proximal ziyabulawa lapho zixhumana nomuthi. I-scolex ekhululiwe ingagaywa emathunjini; ngakho-ke, kungahle kungenzeki ukukhomba i-scolex endle. UNiclosamide Bolus ubulala i-taenicidal futhi akaqedi izingxenye kuphela kepha ne-scolex.
Umsebenzi kaNiclosamide Bolus wokulwa nezibungu ubonakala kungenxa yokuvinjelwa kwe-phosphorylation ye-mitochondrial oxidative; Ukukhiqizwa kwe-anaerobic ATP nakho kuyathinteka.
Umsebenzi we-cestocidal kaNiclosamide Bolus kungenxa yokuvinjelwa kokumunca ushukela nge-tapeworm nasekuqobekeni inqubo yenhlanganisela ye-phosphorylation ku-mitochondria yama-cestode. I-lactic acid enqwabelene ebangelwa ukuvinjelwa komjikelezo weKrebs ibulala izikelemu.
Izinkomba
INiclosamide Bolus ikhonjisiwe ekuhlaselweni yizikelemu zombili kweMfuyo, Izinkukhu, Izinja Namakati kanye ne-paramphistomiasis (Amphistomiasis) engavuthiwe yezinkomo, izimvu nezimbuzi.
Izikelemu zesikhunta
Izinkomo, Izimbuzi Zezimvu Nezinyamazane: I-Moniezia Species Thysanosoma (Izikelemu Zetape Ezinezinqa)
Izinja: IDipylidium Caninum, iTaenia Pisiformis T. hydatigena noT. Taeniaeformis.
Amahhashi: Ukutheleleka nge-anoplocephalid
Izinkukhu: URaillietina noDavainea
I-Amphistomiasis: (Ama-Paramphistomes angavuthiwe)
Ezinkomeni nasezimvwini, iRumen flukes (Paramphistomum species) ivame kakhulu. Ngenkathi ukuqhuma kwabantu abadala okunamathiselwe odongeni lwe-rumen kungabalulekanga kangako, okungakavuthwa kuyingozi enkulu ebangela ukulimala okukhulu nokufa ngenkathi kufuduka odongeni lwe-duodenal.
Izilwane ezibonisa izimpawu ze-anorexia enamandla, ukwanda kokudla kwamanzi, nohudo olunamanzi kufanele kusolwe i-amphistomiasis futhi ilashwe ngokushesha noNiclosamide Bolus ukuvimbela ukufa nokulahleka komkhiqizo njengoba iNiclosamide Bolus ihlinzeka ngokusebenza okuphezulu kakhulu ngokumelene nemikhuhlane engavuthiwe.
Ukwakheka
I-bolus ngayinye engamboziwe iqukethe:
INiclosamide IP 1.0 gm
Ukuphatha kanye nomthamo
UNiclosamide Bolus kokuphakelayo noma kanjalo.
Ngokumelene ne-Tapeworms
Izinkomo, Izimvu namaHhashi: 1 gm bolus yesisindo somzimba esingu-20 kg
Izinja Namakati: 1 gm bolus wesisindo somzimba esingu-10 kg
Izinkukhu: 1 gm bolus yezinyoni ezindala ezi-5
(Cishe i-175 mg ngekhilogremu ngayinye isisindo somzimba)
Ngokumelene nama-Amphistomes
Izinkomo Nezimvu: Umthamo ophakeme ngesilinganiso se-1.0 gm bolus / 10 kg isisindo somzimba.
Ukuphepha:INiclosamide bolus inebanga elibanzi lokuphepha. Ukweqisa ngokweqile kweNiclosamide izikhathi ezingama-40 ezimvwini nasezinkomeni kutholakale ukuthi akunabuthi. Ezinjeni nasemakati, kabili isilinganiso esinconywayo asibangeli miphumela emibi ngaphandle kokuthamba kwendle. INiclosamide bolus ingasetshenziswa ngokuphepha kuzo zonke izigaba zokukhulelwa nasezifundweni ezonakele ngaphandle kwemiphumela emibi
UMKHIQIZO OTHENGISWAYO
Ikhwalithi yokuqala, Ukuphepha kuqinisekisiwe
