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Imikhiqizo yethu

UNiclosamide Bolus 1250 mg

Incazelo emfushane:

INiclosamide Bolus iyi-anthelmintic equkethe iNiclosamide BP Vet, esebenza ngokulwa nezikelemu kanye nezikhukhula zamathumbu ezifana ne-paramphistomum kuma-ruminants.


Imininingwane yomkhiqizo

Amathegi womkhiqizo

UNiclosamide Bolus uvimbela i-phosphorylation ku-mitochondria yama-cestode. Kokubili i-in vitro naku-vivo, izingxenye ze-scolex kanye ne-proximal ziyabulawa lapho zixhumana nomuthi. I-scolex ekhululiwe ingagaywa emathunjini; ngakho-ke, kungahle kungenzeki ukukhomba i-scolex endle. UNiclosamide Bolus ubulala i-taenicidal futhi akaqedi izingxenye kuphela kepha ne-scolex.

Umsebenzi kaNiclosamide Bolus wokulwa nezibungu ubonakala kungenxa yokuvinjelwa kwe-phosphorylation ye-mitochondrial oxidative; Ukukhiqizwa kwe-anaerobic ATP nakho kuyathinteka.

Umsebenzi we-cestocidal kaNiclosamide Bolus kungenxa yokuvinjelwa kokumunca ushukela nge-tapeworm nasekuqobekeni inqubo yenhlanganisela ye-phosphorylation ku-mitochondria yama-cestode. I-lactic acid enqwabelene ebangelwa ukuvinjelwa komjikelezo weKrebs ibulala izikelemu.

Izinkomba

INiclosamide Bolus ikhonjisiwe ekuhlaselweni yizikelemu zombili kweMfuyo, Izinkukhu, Izinja Namakati kanye ne-paramphistomiasis (Amphistomiasis) engavuthiwe yezinkomo, izimvu nezimbuzi.

Izikelemu zesikhunta

Izinkomo, Izimbuzi Zezimvu Nezinyamazane: I-Moniezia Species Thysanosoma (Izikelemu Zetape Ezinezinqa)

Izinja: IDipylidium Caninum, iTaenia Pisiformis T. hydatigena noT. Taeniaeformis.

Amahhashi: Ukutheleleka nge-anoplocephalid

Izinkukhu: URaillietina noDavainea

I-Amphistomiasis: (Ama-Paramphistomes angavuthiwe)

Ezinkomeni nasezimvwini, iRumen flukes (Paramphistomum species) ivame kakhulu. Ngenkathi ukuqhuma kwabantu abadala okunamathiselwe odongeni lwe-rumen kungabalulekanga kangako, okungakavuthwa kuyingozi enkulu ebangela ukulimala okukhulu nokufa ngenkathi kufuduka odongeni lwe-duodenal.

Izilwane ezibonisa izimpawu ze-anorexia enamandla, ukwanda kokudla kwamanzi, nohudo olunamanzi kufanele kusolwe i-amphistomiasis futhi ilashwe ngokushesha noNiclosamide Bolus ukuvimbela ukufa nokulahleka komkhiqizo njengoba iNiclosamide Bolus ihlinzeka ngokusebenza okuphezulu kakhulu ngokumelene nemikhuhlane engavuthiwe.

Ukwakheka

I-bolus ngayinye engamboziwe iqukethe:

INiclosamide IP 1.0 gm

Ukuphatha kanye nomthamo

UNiclosamide Bolus kokuphakelayo noma kanjalo.

Ngokumelene ne-Tapeworms

Izinkomo, Izimvu namaHhashi: 1 gm bolus yesisindo somzimba esingu-20 kg

Izinja Namakati: 1 gm bolus wesisindo somzimba esingu-10 kg

Izinkukhu: 1 gm bolus yezinyoni ezindala ezi-5

(Cishe i-175 mg ngekhilogremu ngayinye isisindo somzimba)

Ngokumelene nama-Amphistomes

Izinkomo Nezimvu: Umthamo ophakeme ngesilinganiso se-1.0 gm bolus / 10 kg isisindo somzimba.

Ukuphepha:INiclosamide bolus inebanga elibanzi lokuphepha. Ukweqisa ngokweqile kweNiclosamide izikhathi ezingama-40 ezimvwini nasezinkomeni kutholakale ukuthi akunabuthi. Ezinjeni nasemakati, kabili isilinganiso esinconywayo asibangeli miphumela emibi ngaphandle kokuthamba kwendle. INiclosamide bolus ingasetshenziswa ngokuphepha kuzo zonke izigaba zokukhulelwa nasezifundweni ezonakele ngaphandle kwemiphumela emibi


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